paratsetamooli

Paratsetamooli, also known as paracetamol or acetaminophen (chemical name N-acetyl-p-aminophenol), is a widely used analgesic and antipyretic. It is available over the counter in many countries and is used to relieve fever and mild to moderate pain such as headaches, dental pain, muscle aches, and osteoarthritis. At usual doses it has limited anti-inflammatory effects compared with many nonsteroidal anti-inflammatory drugs.

Mechanism and use: The exact mechanism is not fully understood, but paratsetamooli is believed to act centrally in the brain to reduce pain and fever, rather than providing strong peripheral anti-inflammatory effects. It is commonly chosen for patients who cannot take NSAIDs, such as those with certain gastric, cardiovascular, or bleeding risks. In addition to adults, it is widely used in children with carefully calculated pediatric dosing.

Forms and administration: Paratsetamooli is available as tablets, capsuled forms, liquid suspensions, chewables, and rectal suppositories. A newer intravenous formulation is used in hospital settings for patients who cannot take oral medications.

Dosing and safety: For adults, typical dosing is 500 to 1,000 mg every 4 to 6 hours as needed, with a maximum daily dose commonly set at 4,000 mg. Pediatric dosing is weight-based and must be closely followed to avoid overdose. It is essential to avoid using multiple products containing acetaminophen at the same time to prevent accidental overdose. People with liver disease, chronic alcohol use, or taking certain medications may require lower doses or avoidance of paratsetamooli. Overdose can lead to severe liver injury and can be life-threatening; seek medical attention urgently if an overdose is suspected. Paratsetamooli is generally considered safe in pregnancy when used as directed.

History: Paratsetamooli was first synthesized in the late 19th century and later reintroduced for medical use in the mid-20th century, with over-the-counter formulations popularized in the 1950s.