rejuvenation

Rejuvenation is a term used to describe processes aimed at restoring youthful function or appearance. In biology and medicine, it refers to interventions intended to reverse or slow aspects of aging at the tissue or organismal level, rather than merely masking signs of aging with cosmetics.

Approaches to rejuvenation span lifestyle factors and biomedical strategies. Caloric restriction and regular physical activity have been associated with markers of healthier aging in both animals and humans. Experimental therapies include senolytics to remove aged cells, agents that modulate metabolism or epigenetic state, and regenerative techniques such as stem cell therapy and tissue engineering. Some work also explores partial cellular reprogramming to reset aging clocks in cells, but results are preliminary and largely limited to laboratory studies or early-stage trials in humans.

Cosmetic rejuvenation methods, such as facelifts, fillers, and laser procedures, aim to restore a more youthful appearance but do not reverse the biological aging of tissues. In scientific and medical contexts, the term often implies efforts to influence fundamental aging processes rather than surface changes alone.

History and status: Interest in reversing aging dates to ancient myths of life-extending elixirs, but modern science began pursuing rejuvenation more systematic ally in the 20th century. Progress includes insights into cellular senescence, the development of induced pluripotent stem cells in 2006, and subsequent work on partial reprogramming. Clinical translation remains limited; most rejuvenation approaches are experimental or in early-stage trials, with no universally approved anti-aging therapy.

Ethical and social considerations include safety, equity of access, and the distinction between health-related rejuvenation and life extension. Regulatory oversight and long-term effects will shape future adoption.