NSARNSAIDs
NSARNSAIDs is not a standard term in pharmacology. It is sometimes used informally to refer to non-selective non-steroidal anti-inflammatory drugs (NSAIDs), a class that inhibits both COX-1 and COX-2 enzymes. In current practice, the recognized term is NSAIDs, with non-selective NSAIDs (nsNSAIDs) describing drugs that block both cyclooxygenase enzymes.
Mechanism and examples: Most nsNSAIDs reversibly inhibit COX-1 and COX-2, reducing synthesis of prostaglandins involved in
Indications and use: nsNSAIDs are used for relief of mild to moderate pain, fever, and inflammatory conditions
Safety and adverse effects: The most frequent adverse effects are gastrointestinal, including dyspepsia, gastritis, ulcers, and
Contraindications and precautions: Avoid in active or high-risk GI bleeding, significant peptic ulcer disease, severe renal
Interactions: nsNSAIDs can interact with anticoagulants, corticosteroids, certain antihypertensives, and alcohol, potentially increasing bleeding or renal