AP2A2

AP2A2 refers to a genetic variant, specifically a polymorphism, in the APOA2 gene. This gene encodes apolipoprotein A-II, a protein that plays a role in lipid metabolism primarily in the middle and late secretory phase of lipid digestion. The AP2A2 variant is characterized by a single nucleotide change from A to C at position 394 of the APOA2 gene.

Research has shown that the AP2A2 variant has been associated with low levels of HDL cholesterol, often referred to as "good" cholesterol. People with this variant may have a slightly increased risk of cardiovascular disease due to their lower HDL levels. However, other factors also influence this association, and more comprehensive studies are needed to confirm its impact.

Studies have also found that the AP2A2 variant is present in a significant number of individuals from European descent. It is estimated to occur in approximately 48% of individuals from the European population, indicating its relatively high frequency in this group.

Some analysis have cautioned that AP2A2 might also be associated with higher risks of dementias including Alzheimer's disease. But the exact nature of this relationship needs more data to be confirmed.

While carriers of the AP2A2 variant may experience some differences in their lipid profiles, they can still benefit from standard lifestyle modifications, such as a balanced diet, regular exercise, and avoidance of smoking, to promote overall cardiovascular health.