hyperfosfatemie
Hyperphosphatemia, also known as hyperfosfatemie, is a condition characterized by an elevated level of phosphate in the blood. In adults, it is generally defined as a serum phosphate concentration above about 1.5 mmol/L (approximately 4.5 mg/dL). It is most commonly seen in chronic kidney disease and end-stage kidney failure, where renal excretion of phosphate is impaired. Other causes include excessive phosphate intake, rapid cell breakdown (such as tumor lysis syndrome or rhabdomyolysis), vitamin D intoxication, hypoparathyroidism, and certain medications or conditions that reduce phosphate clearance or promote shifts of phosphate into the extracellular space.
Pathophysiology typically involves an imbalance between phosphate intake, cellular distribution, and renal excretion. In kidney disease,
Clinical features are often absent until phosphate levels are markedly elevated or complications arise. Symptoms may
Management focuses on treating the underlying cause, restricting dietary phosphate intake, and using phosphate binders (calcium-based