SCH23390
SCH23390 is a potent, selective antagonist of dopamine D1-like receptors, most notably the D1 receptor, with additional activity at the D5 subtype and some affinity for other targets at higher concentrations. It is widely used in neuroscience research to block D1 receptor–mediated signaling and to distinguish D1 effects from those of D2-family dopamine receptors.
Mechanism of action and pharmacology
SCH23390 acts as a competitive antagonist at D1-like receptors. By blocking D1 receptor signaling, it reduces
SCH23390 is used in both in vivo and in vitro settings. In animals, it is employed to
In research, SCH23390 is typically administered systemically (for example, intraperitoneally) or delivered directly into brain regions
Note: This article summarizes its role as a research tool in dopamine D1 receptor pharmacology.