Koejaotuse

Koejaotuse is an Estonian term that denotes the distribution of tissue within a biological sample or anatomical region. In medical and scientific usage, it refers to how different tissue types or cellular components are spatially arranged and proportioned in a given specimen, such as a biopsy, organ section, or engineered scaffold.

The concept is most commonly applied in histology and pathology, where the tissue pattern, organization, and relative abundance of components influence diagnosis, prognosis, and research findings. For example, analyses of tissue distribution can reveal tumor infiltration patterns, fibrosis, or the presence of distinct tissue compartments. In regenerative medicine and tissue engineering, koeaotuse describes how implanted materials integrate with host tissue and how different tissue domains are distributed within a scaffold or graft.

Methodologically, koejaotuse is studied using histological staining, immunohistochemistry, and microscopy, often combined with morphometric and digital image analysis to quantify areas, cell densities, and spatial relationships. Modern approaches may employ three-dimensional imaging, confocal microscopy, and computer-aided segmentation to obtain precise maps of tissue distribution.

In pharmacology and toxicology, the term can also appear in discussions of how a substance distributes across tissues, which is relevant for understanding efficacy and toxicity profiles. While the term is rooted in Estonian medical and scientific literature, the general idea corresponds to broader concepts of tissue distribution used in international biology and medicine.

Etymology: koee (tissue) plus jaotuse (distribution). See also tissue distribution, histomorphometry, and digital pathology.