histomorphometry
Histomorphometry is the quantitative study of bone microstructure and remodeling dynamics through microscopic analysis of histological sections. It provides measurements of architecture (such as trabecular bone volume and thickness) and remodeling parameters (such as formation and resorption rates) to characterize bone health and responses to interventions.
Two main approaches exist: static histomorphometry, which assesses bone at a single point in time, and dynamic
Methods involve preparing undecalcified resin-embedded bone sections, staining (e.g., Goldner’s trichrome, toluidine blue), and histomorphometric analysis
Applications span basic bone biology, osteoporosis research, implant osseointegration, orthodontics, and periodontal/dental tissue research in both