polydioxanone

Polydioxanone (PDO) is a biodegradable, aliphatic polyester derived from the cyclic diester p-dioxanone. It is best known as the material for absorbable surgical sutures marketed under trade names such as PDS. PDO is produced by ring-opening polymerization of p-dioxanone monomer to give poly(p-dioxanone), a semi-crystalline, thermoplastic polymer with ester linkages that undergo hydrolytic degradation in vivo.

In physiological conditions, ester bonds in PDO are cleaved by hydrolysis, leading to gradual loss of mechanical strength and eventual resorption. The degradation is relatively slow compared with some other absorbables, providing prolonged support for wound healing. PDO and its degradation products are generally regarded as biocompatible, with minimal inflammatory response.

In clinical practice, PDO is used to manufacture absorbable sutures that retain tensile strength for weeks to months and are absorbed over months. These sutures are commonly used in soft tissue closure where extended support is advantageous, such as fascia, tissue planes, and pediatric or obstetric procedures. PDO sutures are typically monofilament, though braided formulations exist, and are valued for knot security and predictable resorption.

Beyond sutures, polydioxanone has been explored for temporary implants, tissue engineering scaffolds, and drug-delivery devices, reflecting its balance of initial strength and predictable biodegradation.