metabolismbased
Metabolismbased refers to approaches, strategies, or analyses that are centered on cellular metabolism as a primary driver of biological outcomes. The term describes methods that integrate measurements of metabolic state with computational models to predict, modulate, or optimize function in biology, medicine, and biotechnology. In practice, metabolismbased work emphasizes metabolic pathways, fluxes, and resource allocation alongside genetic or signaling factors.
Core methods include metabolomics, metabolic flux analysis, isotope tracing, and constraint-based modeling. Data are combined with
Applications span medicine, agriculture, and industrial biotechnology. In medicine, metabolismbased strategies target tumor metabolism, metabolic disorders,
Challenges include network complexity, context dependence, and tissue-specific variation. Limitation in measurement accuracy, data integration, and
Related concepts include metabolomics, metabolic engineering, and systems biology, which provide methods and frameworks that underpin