deterioros
Deterioros is a term used in aging research to describe a progressive, systemic decline in physiological function that arises from the accumulation of cellular and molecular damage over time. It is presented as a framework for understanding how multiple subclinical changes can combine to reduce tissue resilience and performance, rather than as a single disease entity. The word is derived from deteriorare, meaning to become worse, and is used to emphasize a gradual, cross-tissue process rather than abrupt pathology.
Deterioros refers to the cumulative deterioration of cellular quality control, energy production, and structural integrity that
Proposed mechanisms include oxidative and metabolic stress, impaired proteostasis, mitochondrial dysfunction, genomic and epigenetic alterations, and
Manifestations are typically subclinical at first, becoming detectable through biomarkers of cellular aging, functional assays, and
Research status and interpretation
Deterioros is a developing concept that coexists with established aging theories. It is useful for framing
See also: aging, senescence, frailty, proteostasis, oxidative stress.