cardiometabole

Cardiometabole is a term used in medical literature to describe the interrelated functioning of cardiovascular and metabolic systems and to refer to conditions in which cardiovascular and metabolic risk factors interact. In many texts, the concept is expressed as cardiometabolic health or cardiometabolic syndrome; in some languages the form cardiométabole or cardiometabole appears as a direct cognate. The term emphasizes that heart and metabolic processes influence each other rather than operate in isolation.

Common components include obesity, insulin resistance, type 2 diabetes, dyslipidemia, hypertension, and nonalcoholic fatty liver disease. Pathophysiology involves insulin signaling disturbances, adipose tissue dysfunction, inflammation, oxidative stress, endothelial dysfunction, and lipid abnormalities, all of which can amplify risk for cardiovascular events and metabolic disease. Lifestyle factors such as physical inactivity and poor diet are major drivers, while genetics modulate susceptibility.

Clinical and public health approaches to cardiometabole stress integrated strategies that address multiple targets simultaneously. Interventions include weight management, exercise, dietary patterns rich in fiber and unsaturated fats, and pharmacotherapy when indicated (for example to control glucose, lipids, or blood pressure). Risk assessment increasingly emphasizes the combined cardiovascular and metabolic profile rather than isolated factors.

Terminology varies by language and discipline, and scholars may use cardiometabolic, cardiometabole, or closely related phrases interchangeably. Clear definition is important in research to avoid ambiguity about what conditions and measurements are included. See also cardiometabolic syndrome, metabolic syndrome, cardiovascular disease, insulin resistance.