bioprintimine
Bioprintimine is a term used in speculative discussions and early-stage research to describe a class of crosslinking systems for 3D bioprinting. In these approaches, imine chemistry is employed to form covalent bonds between reactive groups on polymers and biomolecules, enabling rapid gelation under aqueous, physiological conditions. Bioprintimine formulations are typically integrated into bioinks to increase print fidelity, mechanical stability, and, potentially, biocompatibility with living cells.
There is no single, standardized compound known as bioprintimine. Rather, the term describes a family of imine-based
The core mechanism involves formation of imine bonds, or Schiff bases, between aldehyde- or ketone-functional groups
Applications include tissue-like hydrogels for tissue engineering, organ-on-a-chip models, and cell-laden constructs where rapid gelation, good
Challenges include potential cytotoxicity from aldehyde-containing components, control of degradation and swelling, batch-to-batch variability, and regulatory