SUMOrelated
SUMO-related refers to the cellular and molecular processes that involve SUMOylation, a reversible post-translational modification in which small ubiquitin-like modifier (SUMO) proteins are covalently attached to lysine residues on target proteins. SUMOylation affects protein activity, interactions, localization, and stability, and it participates in numerous cellular pathways.
In humans, the SUMO family includes SUMO-1 and SUMO-2/3, with SUMO-2/3 capable of forming polySUMO chains and
SUMO modifications regulate transcription factors, chromatin structure, DNA damage response, protein stability, and signaling pathways. They
Because SUMOylation affects a broad set of proteins, disruptions are studied in relation to cancer, neurodegenerative
Related concepts include SUMO-interacting motifs (SIMs) and polySUMO chains, and cross-regulation with ubiquitin pathways. The field