The PI3K p110 gamma subunit is the catalytic unit of the PI3K p110 gamma-AR complex, which consists of PI3K p110 gamma and adapter protein p101. PI3K p110 gamma plays a crucial role in signaling pathways involved in immune responses, cell migration, and cell survival. The enzyme is activated by several receptors that mediate inflammatory signals, including G protein-coupled receptors.
Research has implicated PI3K p110 gamma in various diseases and conditions, including asthma, arthritis, and cardiovascular disease. The enzyme also acts as a regulator of airway smooth muscle cell response to inflammatory stimuli. Furthermore, studies have indicated that PI3K p110 gamma activity is necessary for T-cell development and function.
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