KFD

KFD is an acronym that can refer to several different things, depending on the context. The most widely recognized use is for Kikuchi–Fujimoto disease, a rare form of lymphadenitis.

Kikuchi–Fujimoto disease (KFD) is a benign, self-limiting condition characterized by painful swollen lymph nodes, most often in the neck, accompanied by fever and sometimes fatigue or night sweats. It was first described independently by Kikuchi and Fujimoto in 1972. The exact cause is unknown, but several infectious or autoimmune triggers have been proposed. Diagnosis relies on histopathology from a lymph node biopsy, which typically shows patchy necrotizing lymphadenitis with karyorrhexis and an absence of neutrophils; immunohistochemical analysis often reveals predominance of CD8-positive T cells. Laboratory tests may show mild leukopenia or elevated inflammatory markers, but there are no pathognomonic laboratory findings. The differential diagnosis includes lymphoma, tuberculosis, and systemic lupus erythematosus. Treatment is usually supportive, with nonsteroidal anti-inflammatory drugs or analgesics for pain and fever; corticosteroids may be used in severe or persistent cases. The prognosis is generally favorable, with most patients experiencing complete resolution within weeks to months and low rates of relapse.

In other contexts, KFD can be an acronym for various organizations or entities, such as fire departments or governmental agencies, where the initials reflect local or national names. The exact meaning in these cases is determined by context, geography, and the organization involved.