GHmangel
GHmangel, or growth hormone deficiency, is a condition characterized by insufficient production or action of growth hormone (GH) by the pituitary gland, or impaired GH signaling in the body. GH is produced in the anterior pituitary and stimulates growth and metabolism; its release is regulated by hypothalamic releasing and inhibitory hormones, notably GHRH and somatostatin.
Causes of GHmangel include congenital pituitary defects, acquired pituitary disease or injury, brain irradiation, and genetic
Clinical features vary by age. In children, GHmangel typically presents with short stature and slow growth
Diagnosis involves a combination of clinical assessment and laboratory tests. Serum IGF-1 levels are measured as
Treatment most commonly uses recombinant human growth hormone (rhGH) given by daily subcutaneous injections. In children,