E2Faktiivisuus
E2Faktiivisuus refers to the activity of E2F transcription factors. E2Fs are a family of proteins that play a crucial role in the regulation of cell cycle progression and the control of gene expression. They are particularly important for the transition from the G1 phase to the S phase of the cell cycle, which is the period of DNA synthesis.
There are multiple E2F family members, with E2F1, E2F2, and E2F3 often considered the "activator" E2Fs, while
The activity of E2Fs is tightly regulated, primarily through their interaction with retinoblastoma protein (Rb) and
Dysregulation of E2F activity is implicated in various cellular processes, including cancer development. Uncontrolled E2F activation