p130

P130 is a protein encoded by the gene P130, also known as RBL2 (Retinoblastoma-like 2). It is a member of the retinoblastoma (Rb) family of tumor suppressor proteins, which are critical regulators of cell cycle progression, differentiation, and apoptosis. P130 plays a key role in controlling the transition from the G1 to the S phase of the cell cycle, primarily by interacting with E2F transcription factors, thereby inhibiting the transcription of genes necessary for DNA synthesis and cell proliferation.

P130 is characterized by the presence of a pocket domain that mediates its interactions with other regulatory proteins. It is known to be involved in maintaining cellular quiescence and facilitating cell cycle exit, especially in differentiated cells and post-mitotic tissues. Its expression is tightly regulated during development and in response to cellular signals.

Research indicates that P130 functions as a tumor suppressor, with its loss or inactivation associated with various cancers, including retinoblastoma, small-cell lung carcinoma, and other neoplasms. Its activity is modulated through phosphorylation by cyclin-dependent kinases (CDKs), which influence its ability to bind to E2F and other partners.

In addition to its role in cell cycle regulation, P130 contributes to processes such as cellular senescence and differentiation. Its interactions and modifications are subjects of ongoing research, as understanding its pathways could provide insights into cancer development and potential therapeutic strategies.

Overall, P130 is a vital component of the cellular machinery that maintains tissue homeostasis and prevents unchecked cell growth by regulating cell cycle progression through multiple molecular mechanisms.