RBL2

RBL2, also known as the Retinoblastoma-like 2 protein, is a tumor suppressor gene that plays a critical role in cell cycle regulation and differentiation. It is a member of the retinoblastoma protein family, which includes RB1 and RBL1. RBL2 is encoded by the RBL2 gene located on chromosome 13.

The RBL2 protein functions by binding to and inactivating E2F transcription factors, which are essential for the expression of genes involved in cell cycle progression. This binding activity inhibits cell proliferation, promoting a quiescent state or differentiation. RBL2's tumor suppressor activity is often lost in various cancers through mutations, deletions, or epigenetic silencing of the RBL2 gene, leading to uncontrolled cell growth.

Dysregulation of RBL2 has been implicated in the development of several types of cancer, including retinoblastoma, breast cancer, lung cancer, and sarcomas. Alterations in RBL2 can disrupt normal cellular processes, contributing to tumor initiation and progression. Research into RBL2 continues to explore its precise mechanisms of action and its potential as a therapeutic target for cancer treatment. Understanding the role of RBL2 in maintaining genomic stability and controlling cell fate is crucial for advancing our knowledge of cancer biology.