E2F7

E2F7 is a gene that encodes a transcription factor belonging to the E2F family. E2F transcription factors play a crucial role in regulating the cell cycle and DNA replication. Specifically, E2F7 is a transcriptional repressor, meaning it binds to DNA and inhibits the expression of its target genes. Unlike other E2F family members that often require interaction with other proteins like DP proteins to bind DNA, E2F7 can bind to DNA directly and has a unique structure that contributes to its repressive function. It contains two E2F DNA-binding domains and lacks a transactivation domain. E2F7 is thought to regulate the expression of genes involved in cell proliferation, differentiation, and apoptosis. Its precise functions are still being investigated, but studies suggest it acts as a safeguard against uncontrolled cell division. Dysregulation of E2F7 has been implicated in various diseases, including cancer, where its altered expression can contribute to tumor development and progression. Research into E2F7's mechanisms of action and its role in disease is ongoing.