E2F5

E2F5 is a protein that plays a crucial role in cell cycle regulation and DNA repair. It is a member of the E2F transcription factor family, which is involved in the control of cell proliferation and differentiation. E2F5 is encoded by the E2F5 gene, which is located on chromosome 10 in humans.

E2F5 forms a heterodimer with the DP family of proteins, specifically DP1. This heterodimer binds to the E2F DNA binding site, which is a consensus sequence found in the promoters of many genes involved in cell cycle progression and DNA repair. The binding of E2F5-DP1 to the E2F DNA binding site activates the transcription of these genes.

E2F5 is also involved in DNA damage response. In response to DNA damage, E2F5 is phosphorylated by the ATM kinase, which leads to its degradation. This degradation allows the accumulation of E2F1, another member of the E2F family, which binds to the E2F DNA binding site and activates the transcription of genes involved in DNA repair and cell cycle arrest.

E2F5 is highly expressed in rapidly proliferating cells, such as cancer cells. The overexpression of E2F5 has been linked to various types of cancer, including breast, lung, and prostate cancer. However, the exact role of E2F5 in cancer is still not fully understood.

In summary, E2F5 is a transcription factor that plays a crucial role in cell cycle regulation and DNA repair. It forms a heterodimer with DP1 and binds to the E2F DNA binding site to activate the transcription of genes involved in cell cycle progression and DNA repair. E2F5 is highly expressed in rapidly proliferating cells and its overexpression has been linked to various types of cancer.