E2F2

E2F2 is a gene that encodes a transcription factor belonging to the E2F family. These transcription factors play a critical role in regulating the cell cycle, particularly the transition from the G1 phase to the S phase, which is essential for DNA replication. The protein produced by E2F2 is known to bind to specific DNA sequences, thereby activating the transcription of genes involved in cell proliferation. E2F proteins function as dimers, often forming complexes with retinoblastoma protein (Rb) or related pocket proteins. When bound to Rb, E2F2 is typically held in an inactive state. However, during cell cycle progression, Rb is phosphorylated, leading to the release of E2F2 and its activation. This activated E2F2 then promotes the expression of genes required for DNA synthesis and cell division. Dysregulation of E2F2 activity has been implicated in the development of various cancers, where uncontrolled cell proliferation is a hallmark. Research into E2F2 continues to explore its precise regulatory mechanisms and its potential as a therapeutic target in cancer treatment.