E2F3

E2F3 is a gene that encodes a transcription factor belonging to the E2F family of proteins. These proteins play a crucial role in regulating the cell cycle, a fundamental process that controls cell growth and division. E2F transcription factors are known to control the expression of genes involved in DNA replication, cell cycle progression, and apoptosis. Specifically, E2F3 is often found to be upregulated in various types of cancer, suggesting its involvement in tumorigenesis. Its activity is tightly regulated by the retinoblastoma protein (Rb) family, which typically inhibits E2F activity and prevents uncontrolled cell proliferation. Upon cellular signals that promote cell division, Rb proteins are inactivated, allowing E2F transcription factors, including E2F3, to bind to specific DNA sequences and activate the transcription of target genes necessary for cell cycle progression. Dysregulation of E2F3 activity can lead to uncontrolled cell division and is a hallmark of many cancers. Research into E2F3 continues to explore its precise roles in normal development and disease, with potential implications for targeted cancer therapies.