p107

p107 is a protein also known as retinoblastoma-like 2 or RBL2. It is a member of the retinoblastoma protein family, which includes pRB and p107. These proteins are involved in cell cycle regulation and transcriptional repression. p107 primarily functions as a tumor suppressor. It interacts with various transcription factors and E2F proteins, forming complexes that inhibit cell proliferation. Its activity is regulated by phosphorylation, which affects its ability to bind to other proteins. p107 plays a role in maintaining genomic stability and can influence cellular differentiation. Mutations or alterations in p107 expression have been associated with the development of certain cancers, highlighting its importance in preventing uncontrolled cell growth. Research continues to explore the precise mechanisms by which p107 exerts its tumor suppressive functions and its potential as a therapeutic target.