129S6SvEvTac

The 129S6SvEvTac mouse strain, commonly referred to as the 129/Sv strain, is an inbred laboratory mouse model widely used in biomedical research. Developed through selective breeding, this strain is derived from a cross between the 129/Sv and Sv/129 substrains, which originated from wild mice captured in Switzerland. The "Tac" designation indicates that the strain is maintained by Taconic Biosciences, a commercial supplier of laboratory animals.

The 129S6SvEvTac strain is known for its genetic homogeneity, making it a reliable model for studying gene function and disease mechanisms. It carries a high degree of genetic similarity to the 129/SvImJ strain, another commonly used inbred mouse line, but with subtle genetic differences that may influence experimental outcomes. This strain is particularly valued in studies involving gene targeting, as it is often used as a host for embryonic stem cells derived from the 129 background.

The 129S6SvEvTac mouse exhibits typical laboratory mouse traits, including a gray coat color, medium body size, and a docile temperament. It has been utilized in research on cancer biology, neuroscience, immunology, and metabolic disorders. For example, it serves as a background strain for genetically engineered models of cancer, such as those expressing oncogenes or lacking tumor suppressor genes.

Like all laboratory mouse strains, the 129S6SvEvEvTac is maintained under controlled conditions to ensure consistency in experimental results. Breeding colonies are carefully managed to preserve genetic integrity, and the strain is periodically tested for pathogens to maintain specific-pathogen-free (SPF) status. Its widespread use in research reflects its adaptability and the valuable insights it provides into mammalian biology and disease.