129S6SvEvEvTac

129S6/SvEvTac is a commonly used inbred mouse strain that originates from the 129S6 strain combined with the strain designation SvEv (Sullivan- Evans) and the supplier designation Tac (TACSTD, The Jackson Laboratory). It is derived from the Swiss mouse 129 strain, which was one of the first mouse strains inbred for genetic research. The indicated numbers refer to the specific subline of the 129 progenitor and the mutation and breeding underwent at the Institute for Laboratory Animal Sciences at the University of Connecticut. The strain was brought into the animal facility environment by the Jackson Laboratory in the 1930s and the line has been maintained for over 200 generations as a pure inbred strain.

This strain is widely used for transgenic and knockout studies. 129-derived cells are traditionally employed for homologous recombination in embryonic stem cells, and the 129S6/SvEvTac strain provides a compatible host for gene-targeted embryos. The strain is also used in immunology and tumor biology experiments due to its well-characterized immune system and tumor susceptibility profiles. In addition, the strain’s relative rapid growth, ease of housing, and robust breeding performance make it popular for high-throughput screening. The strain carries the standard set of spontaneous mutations typical for the 129 lineage and exhibits phenotypic traits such as a moderate increase in body weight and a reduced lifespan relative to C57BL/6 mice. Standard husbandry conditions for 129S6/SvEvTac include a 12 hour light/dark cycle, standard rodent chow, and a clean, pathogen-free environment. The mouse strain is recommended for use in genetic, developmental, and behavioral studies, requiring careful strain-specific controls in experimental designs.