vCJD
Variant Creutzfeldt-Jakob disease (vCJD) is a rare, acquired prion disease in humans caused by the misfolding and accumulation of prion proteins, typically following exposure to bovine spongiform encephalopathy (BSE) prions through contaminated beef products. It was first identified in 1996 in the United Kingdom, where most cases occurred during the late 1990s; since then, cases have markedly declined due to stricter cattle controls and surveillance.
vCJD tends to affect younger individuals compared with sporadic CJD, with onset commonly in the late 20s
Diagnosis combines clinical presentation with imaging and laboratory tests. MRI may show the pulvinar sign, a
There is no cure or proven disease-modifying therapy; management is supportive. Public health measures to control