piebaldismo
Piebaldism is a rare congenital pigmentary disorder characterized by stable, non-progressive patches of depigmented skin and hair, most notably a white forelock. The condition arises from a defect in melanocyte development, typically due to loss-of-function mutations in the KIT gene, which encodes a receptor tyrosine kinase essential for the migration and survival of melanocytes during embryogenesis. The depigmented patches are usually present at birth and persist throughout life. The affected skin shows absence or markedly reduced melanocytes, while surrounding skin remains normally pigmented. Hair within the depigmented areas, including the forelock, is often white or grey early in life.
Genetics and inheritance: Piebaldism most commonly follows an autosomal dominant pattern with variable expressivity and penetrance.
Clinical spectrum and diagnosis: The hallmark features are a white forelock and depigmented patches on the
Management and prognosis: There is no cure. Management focuses on cosmetic considerations and sun protection. For