leptina
Leptin is a peptide hormone produced predominantly by adipocytes in white adipose tissue. It functions as a hormonal signal of energy stores, circulating in proportion to body fat and acting mainly on receptors in the hypothalamus to regulate appetite and energy expenditure. The leptin gene (LEP) encodes the protein, which is secreted into the bloodstream and crosses the blood–brain barrier to reach its target neurons.
Leptin acts primarily through the leptin receptor (LEPR), particularly the long form LEPRb, expressed in several
Physiological roles extend beyond energy balance to reproduction, immune function, and bone metabolism. Leptin deficiency, due
Therapeutically, recombinant leptin (metreleptin) is approved for certain conditions, including congenital leptin deficiency and generalized lipodystrophy.