kreatinineGFR

KreatinineGFR refers to the estimated glomerular filtration rate calculated from serum creatinine, commonly called an eGFR based on creatinine. It is a widely used metric for assessing kidney function and the stage of chronic kidney disease in adults and some pediatric populations.

Most commonly, KreatinineGFR is computed with equations such as CKD-EPI and MDRD. These formulas adjust serum creatinine for factors including age and sex, and often race, then normalize the result to a standard body surface area of 1.73 m2. The Cockcroft-Gault equation estimates creatinine clearance and has historically been used for drug dosing, but modern practice generally relies on CKD-EPI or MDRD for staging CKD.

Interpretation and use: eGFR values help stage CKD (commonly described as G1 to G5, with higher stages indicating greater loss of function) and inform medication dosing and other management decisions. A normal eGFR is typically 90 mL/min/1.73 m2 or higher, though interpretation also considers markers of kidney damage. However, KreatinineGFR is an estimation, not a direct measurement of filtration, and accuracy can vary by individual factors and clinical context.

Limitations and caveats: Creatinine-based estimates are influenced by muscle mass, diet, hydration, and certain medications or lab assay calibrations. They are less reliable in acute kidney injury, extremes of body size, pregnancy, and some pediatric cases. In such situations, measured GFR using exogenous markers or alternative markers like cystatin C may be used to supplement or verify creatinine-based estimates.