konformaation
Konformaation (konformation) in chemistry describes the set of spatial arrangements of a molecule that arise from free rotation around single (sigma) bonds. Because these rotations do not require breaking bonds, different conformations can interconvert rapidly at typical temperatures. The individual arrangements are called conformers, and an ensemble of all accessible forms constitutes the konformation. This concept is distinct from configurational isomerism, where isomers cannot interconvert without bond making or breaking, such as different stereochemical configurations or cis/trans arrangements.
Many organic molecules exhibit distinct conformations. In alkanes such as n-butane, the main forms are anti
Conformational analysis employs experimental and computational methods. Nuclear magnetic resonance (NMR) spectroscopy can reveal population distributions
Significance lies in how conformational preferences influence reactivity, selectivity, binding interactions in biomolecules and drugs, and