fenamate

Fenamate refers to a class of nonsteroidal anti-inflammatory drugs (NSAIDs) that are derivatives of anthranilic acid. The primary therapeutic action of fenamate NSAIDs is their ability to inhibit cyclooxygenase (COX) enzymes, specifically COX-1 and COX-2. By blocking these enzymes, they reduce the production of prostaglandins, which are key mediators of inflammation, pain, and fever.

The most well-known fenamate NSAIDs include mefenamic acid and flufenamic acid. Mefenamic acid is commonly used for the short-term management of mild to moderate pain, such as menstrual pain (dysmenorrhea) and pain associated with osteoarthritis and rheumatoid arthritis. Flufenamic acid has also been used for similar indications, though it is less commonly prescribed than mefenamic acid in many regions.

Like other NSAIDs, fenamates carry potential side effects. These can include gastrointestinal disturbances such as nausea, dyspepsia, and abdominal pain. More serious risks, though less common, involve gastrointestinal bleeding, ulceration, and perforation. Cardiovascular events, such as increased risk of heart attack and stroke, are also associated with NSAID use, and fenamates are no exception. Renal effects, hypersensitivity reactions, and potential interactions with other medications are also considerations for patients taking fenamates. They are generally not recommended for prolonged use and should be used at the lowest effective dose.