apigenin6Cglucoside

Apigenin 6-C-glucoside is a naturally occurring flavonoid glycoside found in various plants, particularly in the *Apiaceae* family, which includes herbs like parsley, celery, and cilantro. It belongs to the class of apigenin derivatives, where a sugar molecule (glucose) is attached to the flavonoid aglycone via a glycosidic bond at the 6-position of the C-ring. This compound is often studied for its potential biological activities and health benefits.

Chemically, apigenin 6-C-glucoside has a molecular formula of C₂₁H₂₂O₁₁ and is characterized by a 1,3,5-trihydroxy-2-(4-hydroxyphenyl)benzene backbone with a glucose moiety. Its structure distinguishes it from other apigenin glycosides, such as apigenin 7-O-glucoside, due to the position of glucose attachment. The compound is typically extracted from plant sources using solvent-based methods, including ethanol or water-based extractions, followed by purification techniques like chromatography.

Research suggests that apigenin 6-C-glucoside may exhibit antioxidant, anti-inflammatory, and neuroprotective properties. Studies have explored its potential role in modulating cellular pathways, including those involved in oxidative stress and inflammation. Additionally, it has been investigated for its possible effects on cognitive function and protection against neurodegenerative diseases, though more clinical research is needed to confirm these benefits in humans.

Apigenin 6-C-glucoside is generally considered safe due to its natural occurrence, but its pharmacological effects and safety at high concentrations require further investigation. It is often consumed as part of a balanced diet through the consumption of herbs and vegetables rich in flavonoids. Ongoing research continues to elucidate its mechanisms of action and potential therapeutic applications.