VLPbased
VLPbased refers to technologies and products that use virus-like particles (VLPs) as the central platform. VLPs are self-assembled protein shells that resemble authentic viruses in size and morphology but lack infectious genetic material, making them replication-incompetent. The highly ordered arrangement of surface epitopes on VLPs often drives strong antibody responses and can display conformational epitopes similar to those of the native pathogen.
Production and design of VLP-based constructs rely on diverse expression systems, including yeast, insect-cell baculovirus, mammalian
The most established use is vaccines. Hepatitis B surface antigen and HPV L1 VLPs form well-known vaccines
Advantages and challenges include a favorable safety profile and potent immunogenicity from repetitive antigen display, along
Historically, the concept matured in the late 20th century, with first licensed VLP vaccines for HBV and