Sequenzierungsplattformen

Sequenzierung, a German term often translated as sequencing, refers to the process of determining the order of nucleotide bases in a DNA or RNA molecule. This fundamental technique in molecular biology allows scientists to read the genetic code, providing insights into an organism's genetic makeup, its evolution, and its susceptibility to diseases.

The development of sequencing technologies has revolutionized biological research. Early methods, such as the Sanger sequencing method developed by Frederick Sanger in the 1970s, were relatively slow and labor-intensive but provided the first true readouts of DNA sequences. These foundational techniques paved the way for more advanced and high-throughput methods.

Modern sequenzierung techniques, often referred to as next-generation sequencing (NGS) or massively parallel sequencing, have dramatically increased the speed and reduced the cost of determining entire genomes. These technologies allow for the simultaneous sequencing of millions of DNA fragments, enabling rapid analysis of complex genetic material.

The applications of sequenzierung are vast and continue to expand. They include identifying genetic mutations associated with diseases, understanding the mechanisms of gene regulation, studying microbial communities, tracing infectious disease outbreaks, and advancing personalized medicine by tailoring treatments based on an individual's genetic profile. The ability to read and interpret the genetic blueprint is central to many fields of biological and medical science.