Saksenaeaceae

Saksenaeaceae is a family of fungi in the order Mucorales. In traditional classifications it appeared among the zygomycetous fungi, but modern systems often place it within the phylum Mucoromycota. The family comprises the genus Saksenaea, which includes several species, notably Saksenaea vasiformis, a known human pathogen.

Ecology and biology: Members of Saksenaeaceae are mold-forming fungi found in soil, decaying vegetation, and other environmental substrates, particularly in warm, tropical and subtropical regions. They grow as fast-spreading molds and produce sporangia on sporangiophores as part of their asexual reproduction. Like other Mucorales, they have coenocytic hyphae and form characteristic colonies typical of mucoralean fungi.

Clinical relevance: Saksenaea vasiformis is an established opportunistic pathogen capable of causing mucormycosis in humans and animals. Infections are commonly associated with traumatic implantation or surgical wounds and can involve the skin, soft tissues, sinuses, or central nervous system. The clinical course can be rapid and destructive, underscoring the importance of early recognition and treatment.

Diagnosis and treatment: Identification relies on culture and microscopic examination of clinical specimens, supported by molecular methods such as ITS sequencing in some cases. Effective management requires prompt surgical debridement combined with antifungal therapy. Liposomal amphotericin B is commonly used, with consideration of newer agents such as posaconazole or isavuconazole in certain situations. Prognosis improves with early diagnosis and aggressive treatment.