Q61Lare

Q61Lare is a hypothetical protein variant used in theoretical discussions of GTPase signaling and protein regulation. In this construct, the designation denotes a substitution at amino acid position 61, where glutamine (Q) is replaced by leucine (L), combined with a fictional regulatory module named ARE, short for Activation-Regulation Element. The full term is used to identify both the mutation and the accompanying regulatory element in a unified model of signaling dynamics.

Name origin and nomenclature follow a simple convention: Q61 indicates the position of the mutation, L represents the leucine substitution, and are signals the presence of the regulatory element. This combination is designed for thought experiments and computational studies rather than for description of an observed biological variant.

In modeled behavior, Q61Lare is described as altering GTPase activity and effector interactions. The Q61L mutation tends to reduce intrinsic GTP hydrolysis, while the ARE module modulates binding affinities to downstream partners, potentially shaping pathway output, feedback strength, and robustness. Researchers use Q61Lare to explore how regulatory modules can influence signal amplification, cross-talk between pathways, and the response to targeted perturbations in silico.

Origin and usage: Q61Lare originates in speculative or pedagogical literature as a tool for illustrating principles of protein regulation and network dynamics. It is not reported as a naturally occurring variant and has no confirmed experimental validation. It is primarily of interest in discussions of modeling strategies and hypothetical engineering of signaling systems.

See also: Ras family GTPases, Q61 mutations, protein engineering, signaling networks.