Poliglecaprone

Poliglecaprone is a synthetic absorbable polymer used in surgical sutures. It is a copolymer of glycolide and ε-caprolactone and is most commonly encountered in monofilament sutures sold under the trade name Poliglecaprone 25 (often marketed as Monocryl). The polymer is designed to provide high initial tensile strength and to be degraded by hydrolysis with minimal tissue reaction.

Properties and composition: Poliglecaprone sutures are monofilament, which tends to result in low tissue drag and good handling characteristics. The material is absorbed over time through hydrolytic cleavage, with complete absorption typically occurring in about 90 to 120 days. The suture generally retains a portion of its initial strength for the first 1 to 2 weeks and then gradually loses strength as absorption proceeds.

Clinical uses: Poliglecaprone 25 is favored for soft tissue approximation and ligation in general surgery, including subcutaneous and mucosal closures, where rapid absorption is advantageous. It is commonly used in areas such as general surgery, gynecology, urology, and pediatric procedures. It is less suitable for tissues requiring long-term mechanical support or high-tension repairs.

Advantages and limitations: Benefits include predictable absorption, low tissue reaction, and favorable handling due to monofilament structure. Limitations include lack of prolonged tensile strength, higher cost relative to some alternatives, and a need to select materials appropriate to the tissue and clinical situation.

Regulatory and naming notes: Poliglecaprone is the base polymer; Poliglecaprone 25 is the widely used commercial form, and various manufacturers may have related naming while adhering to similar material properties.