PTH134
PTH134 is a fictional gene designation used in educational and illustrative genome annotation exercises to demonstrate common annotation challenges. The label PTH134 is often presented as a locus tag in simulated bacterial genomes to identify a small protein-coding gene.
In the hypothetical genome, PTH134 encodes a protein of about 210 amino acids, with an estimated molecular
Domain predictions place a helix-turn-helix DNA-binding motif in the N-terminal region, consistent with a potential role
Based on gene neighborhood and domain content, PTH134 is proposed to regulate a small operon associated with
Homology analyses indicate only weak similarity to known XRE-like transcription factors, and there are no close
PTH134 is used to illustrate the limitations of automated annotation, such as reliance on domain predictions