PKPDmallinnus
PKPDmallinnus, short for pharmacokinetic-pharmacodynamic modeling, is a framework used to describe and predict how a drug’s concentration in the body relates to its therapeutic and adverse effects. The pharmacokinetic (PK) component describes how the body handles the drug—absorption, distribution, metabolism, and excretion—often through compartmental models that yield concentration-time profiles and parameters such as clearance and volume of distribution. The pharmacodynamic (PD) component describes the drug’s effect as a function of exposure, typically using models like linear, Emax, or sigmoidal Emax (Hill) with parameters such as EC50, Emax, and the Hill coefficient.
Linking PK and PD involves establishing an exposure–response relationship. Direct response models assume an immediate effect
Applications include dose regimen optimization, exposure–response simulations, and supporting dosing in special populations (pediatrics, organ impairment)
Model development relies on data that include concentration measurements and pharmacodynamic endpoints, analyzed with software such