Lufenuron

Lufenuron is a benzoylurea compound that functions as an insect development regulator. It inhibits chitin synthesis, an essential component of the exoskeleton and eggshell in arthropods. By blocking chitin formation, lufenuron disrupts growth and molting, leading to impaired development and reduced emergence of viable offspring rather than immediate death of adults.

In veterinary medicine, lufenuron is widely used as a flea preventive. When administered to dogs or cats, the compound is absorbed into the bloodstream and ingested by feeding fleas. Lufenuron interferes with the fleas’ ability to produce and hatch viable eggs, gradually reducing the flea population on the host and in the environment. It is commonly formulated as oral tablets or topical products and is typically incorporated into integrated flea control programs that include environmental cleaning and, if needed, adulticidal measures.

Administration requires following product labels and veterinary guidance to ensure appropriate dosing and frequency. Lufenuron generally has a favorable safety profile when used as directed, but possible adverse effects can include gastrointestinal upset or hypersensitivity in some animals. Caution is advised for pregnant or lactating animals and those with preexisting health conditions, and drug interactions should be considered.

Regulatory status varies by country, but lufenuron is approved for veterinary use in many jurisdictions. As with other insect growth regulators, its use is managed to balance efficacy with safety and to monitor for potential resistance in pest populations.