LeberOptikusNeuropathie
Leber's Hereditary Optic Neuropathy (LHON) is a rare mitochondrial disorder affecting the optic nerve, leading to progressive vision loss. The disease is inherited in an autosomal dominant pattern, meaning a single copy of the mutated gene is sufficient to cause the condition.
LHON is caused by mutations in the mitochondrial DNA, specifically in the MT-TH, MT-ND1, or MT-ND6 genes.
Symptoms of LHON typically begin with an acute loss of vision in one eye, often due to
Research suggests that LHON may be associated with smoking, and certain mitochondrial genes may increase susceptibility
Low vision rehabilitation programs are often recommended to help individuals with LHON adapt to their vision