Konformationale
Konformationale refers to conformational aspects in chemistry, describing the different shapes a molecule can adopt because single bonds allow rotation. These shapes, called conformers or rotamers, interconvert through bond rotations and are shaped by steric and electronic factors. The term is often used in German-language literature and in translations to denote conformational analysis.
The conformational landscape of a molecule is determined by torsional strain, steric hindrance, and nonbonded interactions.
Characterization methods combine experiments and computation. Nuclear magnetic resonance (NMR) spectroscopy provides information on conformer populations,
Relevance spans chemistry and biochemistry. Konformationale preferences influence reactivity, spectroscopy, and binding in small molecules and