Klorhexidindiglukonat

Klorhexidindiglukonat (also known as chlorhexidine digluconate) is a broad‑spectrum antiseptic and disinfectant widely used in healthcare, dental, and personal hygiene products. It is the sodium salt of chlorhexidine chloride complexed with gluconic acid, a biocidal agent effective against Gram‑positive and Gram‑negative bacteria, yeasts, and some enveloped viruses. The compound functions by binding to bacterial cell membranes, causing leakage of cellular constituents and ultimately cell death. Its activity remains relatively stable across a wide range of pH values, which contributes to its versatility in formulations such as mouthwashes, skin cleansers, and wound‑care antiseptic solutions.

Clinically, chlorhexidine digluconate is frequently applied in pre‑operative skin preparation, surgical scrubs, and to disinfect contaminated surfaces or instruments. In dentistry, it is used as an adjunct to mechanical cleaning to reduce plaque and gingivitis. In oral care, lower concentrations (two percent solutions) provide surface‑level antiseptic benefits, whereas higher concentrations (five to ten percent) are used in wound irrigation or for treating infected mucous membranes. While generally well tolerated, occasional adverse reactions include skin irritation, mucosal discoloration, and in rare cases, allergic contact dermatitis. Its use is contraindicated in individuals with known hypersensitivity to chlorhexidine or glucans. Regulatory approval varies by country, with most nations approving it for topical and in‑water uses while restricting systemic administration due to potential toxicity.