Histaminprovokationstest

Histaminprovokationstest is a diagnostic procedure used to assess the reactivity of the airways to histamine. Histamine is a chemical naturally found in the body that can cause bronchoconstriction, leading to symptoms like coughing, wheezing, and shortness of breath. This test is primarily employed to help diagnose asthma, particularly in cases where standard lung function tests are inconclusive or when there is suspicion of exercise-induced asthma or airway hyperresponsiveness.

During the test, a person inhales increasing concentrations of histamine, usually delivered via an aerosol nebulizer. The procedure begins with a low concentration, and if no significant reaction occurs, progressively higher concentrations are administered. Throughout the test, lung function is monitored, typically by measuring the forced expiratory volume in one second (FEV1). A significant drop in FEV1 after inhaling histamine indicates a positive result, suggesting hyperreactive airways.

The test is performed under strict medical supervision to ensure safety. Bronchodilator medication is readily available to reverse any bronchoconstriction that may occur. A negative test result, where no significant change in lung function is observed even at high histamine concentrations, can help rule out asthma or significant airway hyperresponsiveness. However, it is important to note that a negative result does not entirely exclude asthma, as other factors can influence airway reactivity. The histaminprovokationstest is a valuable tool in the diagnostic arsenal for respiratory conditions.