GTPasebinding
GTPase-binding refers to the interaction between small GTPases of the Ras superfamily and other proteins that recognize the active, GTP-bound conformation of these switches. The term encompasses both effector proteins and modular domains within signaling proteins that specifically bind GTPases in their active state, thereby propagating cellular signals that regulate growth, differentiation, cytoskeleton organization, vesicle trafficking, and gene expression.
Small GTPases act as molecular switches with intrinsic GTPase activity. When bound to GTP, they undergo conformational
Notable GTPase-binding domains include the Ras-binding domain (RBD), found in effectors such as Raf kinases and
GTPase-binding underlies key signaling pathways such as the MAPK cascade, actin cytoskeleton remodeling, and membrane trafficking.