Fibrinreiches

Fibrinreiches is a term used to describe materials or tissues that contain a dense network of fibrin fibers, i.e., a high fibrin content. In biology, fibrin is the insoluble protein formed from fibrinogen by the action of thrombin during coagulation, creating a three‑dimensional mesh that stabilizes blood clots and serves as a provisional extracellular matrix in wound healing. A fibrinreiches material thus has a tight fibrin mesh, often with reduced porosity, trapping cells and platelets and supporting cell migration and growth factor binding.

In practice, fibrin-rich materials are central to hemostasis and tissue repair. They form the scaffold of clots at injury sites and are used in various biomaterials, such as fibrin glue and platelet-rich fibrin products. Platelet-rich fibrin (PRF) and related fibrin-rich concentrates are prepared by centrifugation without anticoagulants, yielding a dense fibrin matrix that releases growth factors over time and supports soft tissue healing. The term fibrinreiches is commonly used in German-language medical literature to describe the fibrin component of clots or biomaterials, as distinct from other components such as platelets or plasma.

Variability in preparation methods, patient factors, and assay conditions can affect the exact fibrin content and network structure, influencing mechanical properties and release kinetics. While fibrin-rich materials have beneficial applications in surgery and regenerative medicine, their use requires consideration of standardization, safety, and clinical context.