Doseerkalkulators

Doseerkalkulators are software tools designed to calculate patient-specific medication dosages or radiopharmaceutical amounts, based on clinical guidelines and pharmacokinetic models, to optimize safety and effectiveness. They are used to translate complex dosing rules into concrete recommendations that account for individual patient characteristics.

They serve a range of purposes in clinical practice, including weight-based dosing, age-based dosing, body surface area-based dosing, and adjustments for renal or hepatic function. Dosing intervals, infusion rates, and combinations of drugs can also be determined, and in some cases they assist with dosing for vaccines, contrast agents, or specialized therapies. Outputs typically include a recommended dose or dose range, frequency, and any cautions or contraindications.

Typical inputs include patient weight, height or body surface area, age, sex, renal function (eg, creatinine clearance or estimated glomerular filtration rate), hepatic function, pregnancy or lactation status, organ impairment, and drug properties such as potency, clearance, and interactions. The calculators present the user with a suggested dose, a permissible range, and the dosing interval, often with notes on limitations and potential adjustments.

Doseerkalkulators are commonly integrated into electronic health record systems, pharmacy software, or available as standalone applications. They function as decision-support tools to aid clinicians but do not replace professional judgment or local guideline requirements. Validation, regular updates, and awareness of guideline changes are essential to maintain accuracy and safety.

Historically, dosing calculations moved from manual calculations and nomograms to computer-assisted systems in the late 20th century, with the rise of mobile and web-based calculators in the 2000s and 2010s. Today, dose calculation tools are widely used across pediatrics, oncology, nephrology, and critical care to support precise, evidence-based dosing.