DFSP
Dermatofibrosarcoma protuberans (DFSP) is a rare, slow-growing malignant skin tumor classified as a soft tissue sarcoma. It is locally aggressive with a high risk of local recurrence after treatment but a low probability of distant metastasis.
DFSP arises from dermal fibroblasts and typically infiltrates into the subcutaneous tissue. It is characterized histologically
Clinically, DFSP presents as a firm, slowly enlarging plaque or nodular lesion on the trunk or proximal
Diagnosis involves biopsy with histopathology and immunohistochemistry. Imaging such as MRI helps assess deep invasion. Molecular
Treatment relies on complete surgical excision with wide margins; Mohs micrographic surgery has high cure rates
Prognosis is generally favorable with appropriate treatment, but the risk of local recurrence remains substantial, potentially
DFSP is rare, with an estimated incidence of about 0.8-5 cases per million people per year. It